Santiago de Chile’s metropolitan region is located in one of the most seismically active subduction zones worldwide, making the area very prone to geohazards such as landslides. In addition, land subsidence by the overexploitation of groundwater affect the ground stability as well. Researchers found that the metropolitan area is uplifting with ca. +10 mm/year, with superimposed local subsidence rates of ca. -15 mm/year. The areas with high subsidence rates are primarily concentrated in sectors with fine grained sedimentary cover and a depressing shallow water table. These results are essential to assess the stability of the area and contribute to future infrastructure development and hazard management in this highly populated metropolitan.